对乙酰氨基酚对帕拉米韦在大鼠体内药动学的影响

Effect of Acetaminophen on the Pharmacokinetics of Peramivir in Rats

考察了对乙酰氨基酚对帕拉米韦在大鼠体内药动学的影响。将健康SD大鼠随机分为试验组和对照组,每组20只。试验组大鼠灌胃给予对乙酰氨基酚50 mg/kg,尾静脉注射帕拉米韦30 mg/kg;对照组仅尾静脉注射帕拉米韦30 mg/kg。采用HPLC法测定血浆中的帕拉米韦,采用DAS 2.0软件拟合药动学参数,并以SPSS 13.0软件比较2组的药动学参数。结果表明,试验组的AUC_(0→3 h)、AUC_(0→∞)、t_(1/2)、CL、V和c_(max)与对照组相比无显著性差异(P>0.05)。本试验结果提示合用对乙酰氨基酚前后帕拉米韦在大鼠体内的药动学无显著性变化。

The effect of acetaminophen on pharmacokinetics of peramivir in rats were investigated. Rats were randomly divided into test group and control group with 20 rats in each. Acetaminophen （50 mg/kg） was given to the test group by garage, and then peramivir （30 mg/kg） was given by intravenous injection via vena caudails, while the animals in the control group were only given peramivir （30 mg/kg） intravenously. An HPLC method was applied for the determination of peramivir concentration in plasma. The pharmacokinetic parameters of the two groups were calculated with DAS 2.0 pharmacokinetic software and were compared by SPSS 13.0 software. The results showed that there were no significant differences in AUC0→3 h、AUC0→∞、t1/2、CL、V and cmax between the control group and the test group （P〉0.05）. It suggested that the pharmacokinetics of peramivir in rats had no significant difference between single administration and co-administration with acetaminophen.