TAFRO综合征一例并文献复习

TAFRO syndrome： a case report with literature review

目的提高对TAFRO综合征的认识。方法报道1例TAFRO综合征的临床特征、实验室检查指标、诊治经过及转归，并进行相关文献复习和讨论。结果男，51岁，表现为发热、双下肢水肿、多浆膜腔积液、血小板减少、肾功能异常；肾穿刺病理提示毛细血管内增生性肾小球肾炎伴血栓性微血管病样改变；淋巴结活检病理支持Castleman病。经糖皮质激素抑制免疫治疗、输注血小板支持治疗后，患者体温恢复正常、浆膜腔积液吸收、血常规恢复良好。结论TAFRO综合征是一组临床症状的组合，准确诊断有赖于综合临床表现、实验室检查及病理学特征，糖皮质激素治疗为首选治疗，临床上需提高对该疾病的认识。

ObjectiveTo better understand the clinical features and the diagnosis of TAFRO syndrome.MethodsThe clinical data of a patient were analyzed and the related literatures were reviewed.ResultsA 51-year-old male characterized by fever, edema of the legs, serous cavity effusion, throm-bocytopenia, and renal dysfunction; Kidney biopsy suggested a diagnosis of endocapillary proliferative glomerulon-ephritis and thrombotic microangiopathy. The pathology of lymph node biopsy supported the diagnosis of Castleman disease. After administering with glucocorticoids and supportive platelet transfusion, the clinical symptoms relieved.ConclusionSymptoms of patients with TAFRO syndrome are variable. The diagnosis relies on history and pathological examination. Currently, glucocorticoids can be used as first line therapy. TAFRO syndrome should be thoroughly investigated for differentiating with other diseases.