丙硫氧嘧啶治疗妊娠合并甲亢的疗效及对妊娠结局的影响研究

Therapeutic effect of propylthiouracil on pregnancy with hyperthyroidism and its effect on pregnancy outcome

目的:研究分析将丙硫氧嘧啶运用到妊娠合并甲亢中的疗效及对妊娠结局的影响。方法:从我院2014年1月-2017年1月收治的妊娠合并甲亢患者中选取40例为研究组,使用药物为丙硫氧嘧啶;选取同时期在我院确诊为妊娠合并甲亢患者40例对照组,未接受药物治疗。将两组患者的相关临床指标以及妊娠结局进行对比分析。结果:研究组的各项相关临床指标(包括促甲状腺激素、总甲状腺素、游离甲状腺素、总三碘甲状腺原氨酸以及游离三碘甲状腺原氨酸)均优于对照组且更接近正常水平,差异具有统计学意义(P <0.05);研究组中共有2例患者妊娠结局不良,其发生率为5.0%,对照组中则有16例患者妊娠结局不良,其发生率为40.0%,两组妊娠结局差异具有统计学意义(P <0.05)。结论:将丙硫氧嘧啶运用到妊娠合并甲亢的治疗中可以有效改善患者的相关临床指标,将其控制在标准范围内,同时可以有效地改善患者的妊娠结局。

Objective： To analyze the efficacy of propylthiouracil on pregnancy with hyperthyroidism and its effect on pregnancy outcome. Methods： 40 patients with pregnancy and hyperthyroidism were enrolled in the study group and treated with propylthiouracil. 40 patients in the same period were selected as the control group and did not receive medical treatment. The clinical indicators and pregnancy outcomes in two groups were compared and analyzed. Results：The relevant clinical indicators （including thyroid stimulating hormone, total thyroxine, free thyroxine, total triiodothyronine and free triiodothyronine） in the study group were superior to the control group and closer to normal levels. The difference was statistically significant （P〈0.05）. There were 2 cases （5.0%） in the study group with poor pregnancy outcome, and 16 cases （40.0%） in the control group had poor pregnancy outcome, the difference is statistically significant （P〈0.05）. Conclusion： Propylthiouracil can effectively improve the clinical indicators of patients with hyperthyroidism in pregnancy, control it within the standard range, and can effectively improve the pregnancy outcome of patients.