子午流注中药结肠保留灌肠对慢性肾衰常见症状的影响

Efficacy of TCM retention enema based on midnight-noon ebb-flow theory on common symptoms of chronic renal failure

目的:观察子午流注中药结肠保留灌肠对慢性肾衰患者的临床效果。方法:采用随机对照的临床试验方法,将符合纳入标准的114例慢性肾衰患者随机分成两组,均按CRF治疗常规给予降压、补血、纠酸等治疗。对照组予尿毒康合剂按照常规行中药保留灌肠,灌肠深度为20～30cm;观察组基于子午流注时间疗法,通过改变灌肠深度和时间,行中药结肠保留灌肠;两组均以14天为一个疗程,每天1次,每周5次,每周间歇2天,观察期为2个月。结果:干预后两组患者的临床症状含倦怠乏力、腰膝酸软、纳呆呕恶、水肿和检验指标含Scr、BUN、Ccr差别均有统计学意义(P <0.05);总体临床疗效分析中,观察组的总体有效率高于对照组(96.36%> 84.75%),差异有统计学意义(P <0.05)。结论:采用子午流注中药结肠保留灌肠可有效改善慢性肾衰患者临床症状和相关肾功能检查指标,改善肾功能,提高患者的生活质量。

Objective： To observe the clinical efficacy of TCM retention enema based on midnight-noon ebb-flow theory on common symptoms of chronic renal failure. Methods： 114 patients with chronic renal failure who met the inclusion criteria were randomly divided into two groups. All patients were treated with routine treatment with aaatihypertensive, blood enriching, and acid treatment. The control group received the Niaodukang mixture （ 尿毒康合剂 ） with the conventional retention enema, enema depth is 20-30cm; the observation group received TCM retention enema based on midnight-noon ebb-flow theory by changing depth and time; two groups were treated 14 days as a course, once a day, 5 times a week, 2 days a week intermittent, with 2 months observation period. Results： The clinical symptoms in two groups with fatigue, anorexia and vomiting, soreness and weakness of waist and knees, edema and test index including Scr, BUN, Ccr were statistically significant difference after intervention （P〈0.05）; In the overall clinical efficacy analysis, the total efficiency in the observation group （96.36%） was higher than 84.75% in the control group （P〈0.05）. Conclusion： TCM retention enema based on midnightnoon ebb-flow theory can effectively improve the clinical symptoms and renal function, and improve the quality of life.