肺结核合并糖尿病耐药机制及其与血糖水平关系

Drug-resistance mechanism of TB combined with diabetes and its relationship with blood glucose level

近些年来很多证据表明糖尿病与肺结核病互为各自患病的重要危险因素之一。罹患糖尿病不仅增加了患结核病的概率及传染性,而且影响了抗结核药物的治疗效果。治疗周期延长、不良反应增加、耐药的产生不仅加重了患者病情与医疗费用,也提高了治疗难度与社会医疗负担。因此,现对其治疗情况之一——耐药机制及其与血糖水平关系作一综述。

There has beena lot of evidence in recent years that diabetes and tuberculosis are major risk fac-tors for inflicting the other diseasse.Diabetes not only increases the risk and infectivity of TB but also affects theeffectiveness of anti-tb drugs. Prolonged treatment cycle, increased adverse reactions and drug resistance not onlyaggravate patients＇ illness and medical expenses but also increase the difficulty of treatment and social and medi-cal burdens.Therefore, the mechanism of drug resistance and its relationship with blood glucose level were reviewed.