吡拉西坦联合奥氮平对老年性痴呆患者记忆力及其智能状态的影响

Effect of piracetam combined with olanzapine on memory and mental state in seniledementia patients

目的探讨吡拉西坦联合奥氮平对老年性痴呆患者记忆力及其智能状态的影响。方法选择2016年5月至2017年7月某院收治的老年性痴呆患者86例,将其按随机对照原则分为两组,各43例。对照组给予奥氮平治疗,观察组在此基础上给予吡拉西坦治疗。比较两组临床疗效、简易智力状态检查量表(mini-mental state examination,MMSE)评分、阳性和阴性症状量表(positive and negative syndrome scale,PANSS)评分及不良反应情况。结果治疗8周后,观察组总有效率(95.35%)高于对照组(79.07%),差异有统计学意义(P<0.05);治疗8周后,两组MMSE总分及各项评分均升高,观察组高于对照组,治疗4、8周后,两组PANSS评分逐渐下降,且各时间点观察组低于对照组,差异有统计学意义(P<0.05);治疗期间,观察组不良反应发生率(9.30%)与对照组(13.95%)比较,差异无统计学意义(P>0.05)。结论吡拉西坦联合奥氮平治疗老年性痴呆具有显著疗效,可明显改善患者记忆力及智能状态,改善临床症状。

Objective To investigate the effect of piracetam combined with olanzapine on memory and mental statein senile dementia patients.Methods 86 senile dementia patients in a hospital from May 2016 to July 2017 were se-lected and divided into two groups by randomized controlled method, with 43 cases in each group.The control groupwas given olanzapine while the observation group was treated with piracetam and olanzapine.The clinical efficacy, mi-ni-mental state examination（MMSE）, positive and negative syndrome scale （PANSS） and adverse reactions were com-pared between the two groups.Results 8 weeks after the treatment, the total effective rate of the observation group（95.35%） was higher than that of the control group （79.07%） and the difference showed statistical significance（P〈0.05）.8 weeks after the treatment, the scores of MMSE and other scores in the two groups increased with the socresof the observation group being higher than those of the control group.4 and 8 weeks after the treatment, the PANSSscores of the two groups gradually decreased and the PANSS score of the observation group was lower than that ofthe control group at different time point and the difference showed statistical significance（P〈0.05）.During treatment,there was no statistical difference in the incidence of adverse reactions between the observation group （9.30%） andthe control group （13.95%） and the difference showed no statistical significance（P〉〈0.05）.Conclusion Piracetamcombined with olanzapine in the treatment of senile dementia achieved remarkable effect.It can improve the memoryand mental state of patients and clinical symptoms.