甲泼尼龙联合阿奇霉素治疗小儿难治性支原体肺炎的疗效与安全性

Efficacy and safety of methylprednisolone combined with azithromycin in the treatment of refractory mycoplasma pneumonia in children

目的:探讨甲泼尼龙联合阿奇霉素治疗小儿难治性支原体肺炎的临床效果。方法:收治小儿难治性支原体肺炎患儿82例,按照入院先后顺序分为对照组和观察组,每组各41例。对照组给予阿奇霉素治疗,观察组给予阿奇霉素联合甲泼尼龙治疗,对比两组患儿治疗后CRP水平、临床症状的改善情况,以及治疗后不良反应的发生情况。结果:治疗后,观察组患儿CRP水平明显优于对照组,肺部阴影、咳嗽、发热等症状改善情况明显优于对照组,呕吐、头晕、恶心、面部潮红等不良反应发生率明显低于对照组(P<0.05)。结论:针对小儿难治性支原体肺炎使用甲泼尼龙联合阿奇霉素进行治疗的效果明显好于单独使用阿奇霉素。

Objective：To explore the clinical effect of methylprednisolone combined with azithromycin in the treatment of refractory mycoplasma pneumonia in children.Methods：82 children with refractory mycoplasma pneumonia were divided into the control group and the observation group according to the order of admission.The control group was treated with azithromycin,and the observation group was treated with azithromycin combined with methylprednisolone.The levels of CRP, the improvement of clinical symptoms and the occurrence of adverse reactions were compared between the two groups.Results：After the treatment,the level of CRP in the observation group was significantly higher than that in the control group,the improvement of lung shadow, cough,fever and other symptoms was significantly better than that in the control group,and the incidence of adverse reactions such as vomiting,dizziness,nausea,facial flushing was significantly lower than that in the control group（P 〈0.05）.Conclusion： Methylprednisolone combined with azithromyein is better than azithromyein alone in the treatment of refi＇aetory myeoplasma pneumonia in children.