肺腺癌伴区域淋巴结转移患者临床及分子病理特征分析

Clinical and molecular pathological characteristics of patients with pulmonary adenocarcinoma with regional lymph node metastasis

目的:探讨肺腺癌伴区域淋巴结转移患者临床及分子病理特征。方法:收治肺腺癌伴区域淋巴结转移患者210例,获取患者EGFR、ALK、ROS1及RET等基因检测结果,分析其基因状态和病理特征。结果:210例患者中,EGFR突变率42.86%,ALK、ROS1及RET阳性率分别为10.95%、1.9%、3.33%;EGFR和ALK均为阳性4例,所有基因检测均为阴性89例。EGFR突变组患者和ALK阳性组患者的病理分化程度比较差异有统计学意义(P<0.05)。结论:肺腺癌伴区域淋巴结转移患者EGFR、ALK、ROS1及RET基因在临床病理特征上具有共性。

Objective：To explore the clinical and molecular pathological characteristics of patients with pulmonary adenocarcinoma with regional lymph node metastasis.Methods：210 patients with pulmonary adenocarcinoma with regional lymph node metastasis were selected,we obtained EGFR,ALK,ROS1 and RET gene test results,and analyzed the genetic status and pathological characteristics.Results：In 210 patients,the mutation rate of EGFR was 42.86%,the positive rates of ALK,ROS1 and RET were 10.95%,1.9% and 3.33% respectively.Both EGFR and ALK were positive in 4 cases,all the genetic tests were negative in 89 cases.In EGFR mutation group and ALK positive group,there was significant difference in the degree of pathological differentiation between the two groups（P〈 0.05）.Conclusion：EGFR,ALK,ROS1 and RET genes were common in clinicopathological features of patients with pulmonary adenocarcinoma with regional lymph node metastasis.