哺乳动物雷帕霉素靶蛋白信号通路在心脏发育和重构中作用的研究进展

Research Progress of mTOR Signaling Pathway Effect in Cardiac Development and Reconstruction

哺乳动物雷帕霉素靶蛋白(mTOR)是一种非典型的丝氨酸/苏氨酸蛋白激酶,其行使生理功能主要通过两种不同的蛋白质复合体mTORC1和mTORC2。mTORC1调节蛋白质的合成、细胞的生长增殖,而mTORC2调节细胞的存活。研究表明,mTOR在心脏发育和重构中发挥关键调节作用。寻找心脏特异性mTORC1的抑制剂,而不损害其生理功能,可能为心血管疾病治疗提供新思路。

The protein kinase mammalian or mechanistic target of rapamycin（mTOR）is an atypical serine-threonine kinase that exerts its main cellular functions by 2 different multiprotein complexes,mTOR complex 1（mTORC1）and mTOR complex 2（mTORC2）.The mTORC1 regulates protein synthesis,cell growth and proliferation,autophagy and cell metabolism,whereas mTORC2 regulates cell survival.Studies have shown that the mTOR pathway plays a key regulatory function in cardiac development and reconstruction.Looking for specific mTORC1 inhibitor,without compromising physiological function of mTOR,may provide new ideas for the treatment of cardiovascular disease.