高血压导致主动脉夹层发病机制的研究进展

Review of Mechanisms of Aortic Dissection in Patients of Hypertension

主动脉夹层的发病率明显增加,病死率高,严重威胁患者生命。在导致主动脉夹层发生的病因中,高血压是最常见的一种。目前认为,血流动力学改变、血管壁病理性改变以及分子免疫因素参与疾病的发生发展;但具体的发病机制仍不明确。现综述高血压导致主动脉夹层发病机制的研究进展,希望为进一步研究主动脉夹层的发病机制奠定基础,为主动脉夹层的防治提供理论指导。

Aortic dissection threats patients lives with high morbidity and mortality.Of the several causes of aortic dissection,hypertension is the most common.It is widely agreed that the dynamic influences of blood,pathological changes of vessel walls,molecular and immunology mechanisms participate in the occurrence and development of aortic dissection.However,the definite mechanisms are not clear yet.We review the recent articles published in domestic and foreign journals,aiming to help us for further research and clinical practice of aortic dissection.