不同年龄抑郁障碍患者bFGF的表达

The Difference of Expression of Basic Fibroblast Growth Factor in Different Age Groups with Depressive Disorder

目的研究碱性成纤维细胞生长因子在不同年龄段抑郁障碍患者及正常对照组中的表达差异,为抑郁障碍的发病机制研究提供实验依据.方法共入组253人,随机分为抑郁组143人,正常对照组110人.使用酶联免疫吸附测定(ELISA)方法分别测定两组血清中的促血管生长因子——碱性成纤维细胞生长因子(bFGF).将2组的碱性成纤维细胞生长因子测定结果分为<30岁和≥30岁,<40岁和≥40岁以及<50岁和≥50岁.结果(1)抑郁障碍组和正常对照组2组组间比较,bFGF差异无明显统计学意义(P>0.05).(2)在抑郁障碍患者组中,各年龄段患者的bFGF差异无明显统计学意义(P>0.05).(3)在正常对照组中,30岁以上者的bFGF高于30岁以下者(P<0.05);40岁以上者的bFGF高于40岁以下者(P<0.05);50岁以上及50岁以下者的bFGF差异无明显统计学意义(P>0.05).结论碱性成纤维细胞生长因子(bFGF)与抑郁障碍的发病机制的关系尚不明显.

Objective To study the difference of expression of basic fibroblast growth factor（bFGF） in different age groups with depressive disorder and normal control group, and to provide experimental basis for the study of the pathogenesis of depressive disorder. Methods A total of 253 people were randomly divided into a depression group of 143 and a normal control group of 110. The angiogenic bFGF in serum of two groups was measured by enzyme-linked immunosorbent assay（ELISA）. The results of two groups of basic fibroblast growth factor were divided into less than 30 years and more than 30 years old, less than 40 years and older than 40 years old and 50 years old and above 50 years.Results（1）The difference of bFGF between the two groups of depressive disorder group and normal control group was not statistically significant（P 〉 0.05）.（2）In the depressive disorder group, the bFGF difference in each age group was not statistically significant（P 〉 0.05）.（3）In the normal control group,the bFGF of people over 30 years old was higher than those under 30 years old（P 〈 0.05）; BFGF was higher in people over 40 years of age than those under 40 years old（P 〈 0.05）;there was no significant difference in bFGF between 50 years old and 50 years old（P 〉 0.05）. Conclusion The relationship between bFGF and the pathogenesis of depressive disorder is not obvious.