重症中暑心脏损伤机制的研究进展

Advances in the mechanism of heart injury in severe heat stroke

重症中暑是中暑最为严重的一种,常伴有多脏器功能障碍,具有高病死率和高致残率的特点。心血管功能障碍常见于重症中暑多脏器功能障碍患者,目前对其病理生理机制的认识不足,是临床预防和治疗重症中暑心功能障碍缺乏有效手段的重要原因。因此,本文围绕中暑导致心血管系统功能障碍、心脏损伤及相关分子生物学机制的研究进展进行综述,以更好地了解重症中暑所致心功能障碍,进一步为临床有效治疗提供新的思路。

Sever heat stroke, a life-threatening condition with high mortality and disability, is often accompanied withby multi-organ dysfunction syndrome （MODS）. Cardiovascular dysfunction is common in heatstroke patients with multiple organ dysfunction syndrome. At present, the lack of understanding of its pathophysiological mechanism of cardiac dysfunction, is the main reason why there is insufficient prevention and treatment strategies for heat-induced cardiac dysfunction. Therefore, we provide a comprehensive review of recent advances in the cardiovascular dysfunction, heart injury and related molecular biological mechanism in heat stroke, aims to better understand the cardiac dysfunction caused by heat stroke and provide ideas for clinical effective treatment.