摘要
通过合成生物学技术可以实现化学品的生物合成,从而为摆脱石油资源依赖提供了可能。合成生物学技术的发展极大地提高了微生物细胞工厂生产化学品的能力,创造的新菌种、新工艺可以有效替代传统工艺,显著降低污染,大幅减少能耗,提升传统发酵行业的技术水平。文章对利用合成生物学技术构建细胞工厂以及构建多酶分子机器来生产化学品的关键因素和典型案例进行了综述,并对合成生物学技术工业应用的未来进行了展望。
Biosynthesis of chemicals through synthetic biology can partially relieve the dependence on petroleum resources. With the development of synthetic biology technology, the capabilities of constructing microbial cell factories for production of chemicals have been greatly improved. Development of new engineered strains and new bioprocess can replace the traditional manufacturing process, decrease the energy cost and pollution, and improve the producing capabilities of traditional fermentation industry. In this review, key factors and representative cases for constructing microbial cell factories and multi-enzyme molecular machines to produce chemicals were summarized. The future of industrial applications of synthetic biology were also discussed.
作者
曾艳
赵心刚
周桔
ZENG Yan;ZHAO Xingang;ZHOU Ju(Bureau of Science & Technology for Development,Chinese Academy of Sciences,Beijing 100864,China)
出处
《中国科学院院刊》
CSCD
北大核心
2018年第11期1211-1217,共7页
Bulletin of Chinese Academy of Sciences
关键词
合成生物学
化学品
细胞工厂
多酶分子机器
synthetic biology
chemicals
cell factories
multi-enzyme molecular machines