甘露糖结合蛋白在棘阿米巴性角膜炎致病机制中的研究进展

Research progress of mannose-binding protein in pathogenesis of Acanthamoeba keratitis

棘阿米巴性角膜炎是一种严重的致盲性眼病,其病原体棘阿米巴是一种机会致病原虫,具有多种毒力因子。目前研究表明,引起棘阿米巴性角膜炎发病的关键始动因子是甘露糖结合蛋白,其可介导棘阿米巴黏附在宿主角膜细胞上,引起宿主细胞发生病理变化,并逃避免疫细胞的降解。本研究有助于揭示棘阿米巴性角膜炎的分子发病机制,为寻找药物治疗的新靶点提供依据。

Acanthamoeba keratitis is a severe blinding eye disease, and its pathogen Acanthamoeba is an opportunistic pathogen with multiple virulence factors. According to the current researches, one of the most important initial factors is the mannose-binding protein （MBP）, which mediates the adhesion of Acanthamoeba to the host corneal cells, causing the pathological changes of the host cells and avoiding being degraded by the immune cells. This study will help to reveal the molecular pathogenesis of Acanthamoeba keratitis, and provide a basis for fnding new targets for drug therapy.