摘要
目的:分析联合应用利培酮、丙戊酸钠对具有攻击行为的精神分裂症患者的有效性和安全性。方法:择取66例具有攻击行为的精神分裂症患者进行临床研究,应用随机数表法将其分为单药组及联合组各33例,单药组仅应用利培酮治疗,联合组应用利培酮和丙戊酸钠治疗,比较两组用药的有效性及安全性。结果:治疗6周及12周时,联合组BPRS、MOAS水平均显著低于单药组,差异有统计学意义(P<0.05);疗程结束时,联合组的痊愈率为45.45%(15/33),显著高于对照组的21.21%(7/33),差异有统计学意义(P<0.05);联合组总有效率为100.00%(33/33),与单药组的90.91%(30/33)比较,差异无统计学意义(P>0.05);联合组不良反应发生率为63.64%(21/33),与单药组的54.55%(18/33)比较,差异无统计学意义(P>0.05)。结论:利培酮联合丙戊酸钠治疗具有攻击行为的精神分裂症患者的疗效较好,且安全性佳。
Objective: To analyze effcacy and safety of Risperidone combined with Sodium valproate in treatment of aggressive behaviors in the schizophrenics. Methods: 66 schizophrenia patients with aggressive behaviors were selected for clinical study. They were divided into single drug group and combined drug group with 33 cases in each. The single drug group was treated with Risperidone only, while the combined drug group was treated with Risperidone and Sodium valproate. The effcacy and safety were compared between the two groups. Results: 6 and 12 weeks after the treatment, the levels of BPRS and MOAS in the combined drug group were signifcantly lower than those in the single drug group, and the difference was statistically signifcant (P〈0.05). At the end of the treatment, the cure rate of the combined drug group was 45.45% (15/33), which was signifcantly higher than that of the control group (21.21%, 7/33), and the difference was statistically signifcant (P〈0.05). The total effective rates of the combined drug group and the single drug group were 100.00% (33/33) and 90.91% (30/33), respectively, and the difference was not statistically signifcant (P〉0.05). Further, the adverse reaction rates of the combined drug group and the single drug group were 63.64% (21/33) and 54.55% (18/33), respectively, and the difference was not statistically signifcant (P〉0.05). Conclusions: Risperidone combined with Sodium valproate in the treatment of aggressive behaviors in the schizophrenics is more effective with good safety.
作者
李天平
LI Tianping(The Second People's Hospital of Gaoyou,Yangzhou Jiangsu 225600,China)
出处
《中国民康医学》
2018年第22期67-68,71,共3页
Medical Journal of Chinese People’s Health
关键词
精神分裂症
攻击行为
利培酮
丙戊酸钠
联合用药
Schizophrenia
Aggressive behavior
Risperidone
Sodium valproate
Drug combination