亚抑菌浓度抗生素对细菌耐药性和毒力影响的研究进展

Effects of sub-inhibitory concentration of antibiotics on bacterial resistance and virulence:A review

细菌的耐药性和毒力是决定抗生素治疗成败的关键。近年来研究表明亚抑菌浓度抗生素可以诱导细菌耐药并影响细菌的毒力。本文介绍了亚抑菌浓度抗生素产生的来源;阐述了亚抑菌浓度抗生素对细菌耐药性和毒力的影响。亚抑菌浓度抗生素对细菌耐药性的影响涉及了细菌的耐药选择性、生物被膜和持留菌的形成、基因突变、水平基因转移和基因表达;对细菌毒力的影响主要包括细菌的黏附性、运动性和其它毒力因子。以期为畜牧生产中减少和避免亚抑菌浓度抗菌药的产生,减缓和克服细菌耐药性,降低致病菌的毒力提供参考。

Antibacterial resistance and bacterial virulence is the key factor to determine the treatment effect of antibioticsis the determinant of whether the bacteria can infect the host. In recent years, the problem of antibacterial resistance has been paid attention, and the virulence of bacteria also causes widespread concern. The origins of sub-inhibitory concentration of antibiotics were introduced in this paper. Influences of sub-inhibitory concentration of antibiotics on the bacterial resistance and virulence were summarized. The effects of the sub-inhibitory concentration of antibiotics on bacterial resistance is related to the selective resistance, bio-film formation, persisters, gene mutation, horizontal gene transfer and gene expression. The effects of the sub-inhibitory concentration of antibiotics on bacterial virulence were also described, such as bacterial adhesion, motility and other virulence factors. This review aims to deliver the knowledge on the theoretical basis for reducing and avoiding the emergence of drug resistance regarding the sub-inhibitory concentration in livestock production, to slow down and overcome drug resistance and to reduce the virulence of pathogenic bacteria.