局部晚期宫颈癌放射治疗

Radiotherapy for locally advanced cervical cancer

宫颈癌在发展中国家发病率仍较高,其中接近80%患者诊断为局部晚期宫颈癌(LACC)。美国国立综合癌症网络(NCCN)Ⅰ类推荐LACC患者治疗为盆腔放射治疗+腔内后装治疗+顺铂为基础同步化疗,目前LACC患者5年生存率仍徘徊在70%左右。文章结合相关文献,简述LACC患者放射治疗基本方法、原则及疗效,同时就提高放疗效果措施及进展,包括精准放疗、同步化疗、新辅助化疗、放疗后巩固化疗、手术病理分期及联合靶向治疗相关临床应用及研究展开综述及讨论。

The incidence of cervical cancer is still high in developing countries.Nearly 80% are diagnosed as locally advanced cervical cancer（LACC）.The National Comprehensive Cancer Network（NCCN）recommends that LACC patients be treated with pelvic radiotherapy,intracavitary brachytherapy and cisplatin-based concurrent chemotherapy.At present,the 5-year survival rate of LACC patients is still around 70%.In this paper,the basic methods,principles and therapeutic effects of radiotherapy for LACC patients are briefly reviewed,and the progress of radiotherapy,including precise radiotherapy,concurrent chemotherapy,neoadjuvant chemotherapy,post-radiotherapy consolidated chemotherapy,surgical pathological staging and combined targeted therapy,is reviewed and discussed.