有机锡5-甲基/氨基-1H-四唑乙酸酯的合成、结构与抗肿瘤活性（英文）

Syntheses,Structures and Antitumor Activities of Organotin 5-Methyl/amino-1H-tetrazolyl-1-acetates

通过5-甲基/氨基-1H-四唑乙酸与(R3Sn)2O(R为苯基或正丁基)及三环己基氢氧化锡的反应,合成了5个三有机锡5-甲基/氨基-1H-四唑乙酸酯。通过核磁,红外及X射线单晶衍射分析,对这些化合物进行了详细的结构表征。结果表明,这些化合物往往通过分子间的Sn…N作用形成配位高分子。初步的生物活性测试表明,这些配合物对Hela和A549细胞具有明显的体外细胞毒性。

Five triorganotin 5-methyl-1H-tetrazolyl-1-acetates and 5-amino-1H-tetrazolyl-1-acetates have been synthesized by the reaction of （R3Sn）2O （R=Ph or n-Bu） or Cy3SnOH （Cy=cyclohexyl） with 5-methyl-1H-tetrazolyl-1-acetic acid or 5-amino-1H-tetrazolyl-1-acetic acid. All the complexes were characterized by elemental analysis, IR and multinuclear NMR （1H, 13C and 119Sn）. Their structures have been confirmed by the X-ray single crystal diffraction analysis, suggesting that they form linkage coordination polymers through the intermolecular Sn…N interactions. The cytotoxic activity of the complexes for Hela and A549 cells was tested, showing that most of them displayed good cytotoxicities for these two cells in vitro.