枯草杆菌二联活菌辅助治疗对溃疡性结肠炎患者IL-8、MDA和TNF-α水平的影响

Effect of adjuvant treatment of Bacillus subtilis and live bacteria secondary-united therapy on levels of IL-8,MDA and TNF-α in ulcerative colitis patients

目的研究枯草杆菌二联活菌辅助治疗溃疡性结肠炎(UC)的临床疗效。方法选取我院收治的UC患者116例为研究对象,随机将患者分成对照组(58例)和观察组(58例)。两组患者均接受受美沙拉嗪治疗,观察组在此基础上加用枯草杆菌二联活菌肠溶胶囊。对比两组患者的临床疗效。结果观察组的治疗总有效率明显高于对照组(P<0.05);治疗后,两组患者的IL-8、MDA、TNF-α水平均显著降低,且观察组均明显低于对照组(P<0.05)。两组患者的不良反应总发生率无显著差异(P>0.05)。结论枯草杆菌二联活菌肠溶胶囊辅助美沙拉嗪可有效调节UC患者的炎症水平,疗效显著,安全性高。

Objective To study the clinical efficacy of Bacillus subtilis and live bacteria secondary-united therapy in theadjuvant treatment of patients with ulcerative colitis （UC）. Methods A total of 116 patients with UC in our hospital wereselected and randomly divided into control group （58 cases） and observation group （58 cases）. Both groups receivedmesalazine, and the observation group added Bacillus subtilis and live bacteria enteric capsules secondary-united therapy.The clinical efficacy of the two groups were compared. Results The total effective rate of treatment in the observation groupwas significantly higher than that in the control group （P〈0.05）. After treatment, the levels of IL-8, MDA and TNF-琢 in thetwo groups significantly decreased, and those in the observation group were significantly lower than the control group （P〈0.05）. There was no significant difference in the total incidences of adverse reactions between the two groups （P〉0.05）.Conclusion Bacillus subtilis and live bacteria secondary-united therapy with mesalazine can effectively regulate the level ofinflammation in patients with UC, with remarkable curative effect and high safety.