孟鲁司特钠联合酮替芬治疗咳嗽变异性哮喘的临床效果

Clinical effect of montelukast sodium combined with ketotifen in the treatment of cough variant asthma

目的探讨孟鲁司特钠联合酮替芬治疗咳嗽变异性哮喘的临床效果。方法在本院2015年12月至2017年12月收治的咳嗽变异性哮喘患者中选取98例作为研究对象,并按给药方案不同分为对照组(n=49,单纯采用酮替芬治疗)和研究组(n=49,应用孟鲁司特钠联合酮替芬治疗)。比较两组患者治疗效果、复发率、肺功能指标水平及咳嗽评分。结果研究组患者的治疗总有效率为95.92%,显著高于对照组的81.63%,差异具有统计学意义(P<0.05)。研究组患者复发率是2.13%,显著低于对照组的16.67%,差异具有统计学意义(P<0.05)。治疗后,两组患者的肺功能指标FVC、FEV1、MVV水平均升高,且研究组显著高于对照组,差异具有统计学意义(P<0.05);两组患者的日间、夜间咳嗽评分均降低,且研究组低于对照组,差异具有统计学意义(P<0.05)。结论孟鲁司特钠联合酮替芬治疗咳嗽变异性哮喘的临床效果确切,值得临床推广应用。

Objective To explore the clinical effect of montelukast sodium combined with ketotifen in the treatment ofcough variant asthma. Methods A total of 98 patients with cough variant asthma admitted in our hospital from December2015 to December 2017 were selected as study objects. According to the different administration schedules, the patientswere divided into control group （n=49, treated with ketotifen alone） and study group （n=49, treated with montelukastsodium combined with ketotifen）. The treatment effects, recurrence rate, levels of pulmonary function indexes and coughscores were compared between the two groups. Results The total effective rate of treatment in the study group was95.92%, which was significantly higher than 81.63% of the control group, the difference was statistically significant （P〈0.05）; The recurrence rate in the study group was 2.13%, which was significantly lower than 16.67% of the controlgroup, the difference was statistically significant （P〈0.05）. After treatment, the levels of lung function indicators such asFVC, FEV1 and MVV in the both groups increased, and those of the study group were sgnificantly higher than the controlgroup, the differences were statistically significant （P〈0.05）; the daytime and nighttime cough scores of the two groupsdecreased, and those in the study group were lower than the control group, the differences were statistically significant（P〈0.05）. Conclusion Montelukast sodium combined with ketotifen in the treatment of cough variant asthma hasaaccurate clinical effect. It is worthy of popularization and application in clinic.