217例直肠癌患者的生存情况及相关影响因素分析

Analyze of survival status and related influencing factors of 217 patients with rectal cancer

目的分析直肠癌患者的生存情况及相关影响因素。方法回顾性分析2008年7月至2014年7月我院收治的217例直肠癌患者的临床资料,对其生存情况进行分析,采用单因素及Cox多因素分析探讨影响患者生存的主要因素。结果 217例直肠癌患者的1年生存率为59.98%,3年生存率为38.36%。单因素分析显示,肿瘤类型、Dukes分期、分化程度、有无淋巴结转移、邻近器官受累及手术方式是影响直肠癌患者预后的相关因素(P<0.05)。Cox多因素分析结果显示,Dukes分期、分化程度、淋巴结转移及邻近器官受累是影响直肠癌患者预后的独立危险因素(P<0.05)。结论影响直肠癌患者预后的因素较多,临床应综合考虑,给予患者个体化治疗方案。

Objective To analyze the survival status and related influencing factors of rectal cancer patients. MethodsThe clinical data of 217 patients with rectal cancer admitted in our hospital from July 2008 to July 2014 were retrospectivelyanalyzed, the survival status were analyzed. The main factors affecting the survival of patients were analyzed by single factorand Cox multifactors analysis. Results The 1-year survival rate of 217 patients with rectal cancer was 59.98%, and the 3-year survival rate was 38.36%. Single factor analysis showed that the tumor type, Dukes stage, differentiation, lymph nodemetastasis, adjacent organ involvement and surgical methods were relevant factors for the prognosis of patients with rectalcancer（P〈0.05）. Cox multifactors analysis showed that Dukes stage, differentiation, lymph node metastasis and adjacent organinvolvement were independent risk factors affecting the prognosis of patients with rectal cancer（P〈0.05）. Conclusion Thereare many factors affecting the prognosis of patients with rectal cancer, and comprehensive considerations should be given inclinical practices to give individualized treatment plans for patients.