影响COPD急性加重期患者预后的相关因素分析

Analysis of factors affecting the prognosis of patients with acute exacerbation of COPD

目的分析影响慢性阻塞性肺疾病急性加重期(AECOPD)患者预后的相关因素。方法选择我院有完整临床资料的119例AECOPD患者,对其临床资料进行分析,探讨影响患者预后的相关危险因素。结果单因素分析结果显示,年龄、呼吸衰竭、抗氧化剂、血肌酐水平、外围淋巴细胞计数及PaCO_2水平是影响AECOPD患者预后的相关因素(P<0.05)。多因素Logistic回归分析结果显示,年龄、外周淋巴细胞计数及PaCO_2水平是影响AECOPD患者预后的独立危险因素(P<0.05)。结论影响AECOPD患者预后的影响因素较多,临床应对年龄>60岁、低外周淋巴细胞计数及高PaCO_2水平患者重点监测,采取有效措施改善患者预后。

Objective To analyze the factors affecting the prognosis of patients with acute exacerbation of chronicobstructive pulmonary disease （AECOPD）. Methods A total of 119 patients with AECOPD who had complete clinical datawere enrolled, the clinical data of patients were analyzed to explore the relevant risk factors affecting the prognosis. ResultsThe univariate analysis showed that age, respiratory failure, antioxidants, the level of serum creatinine, peripheral lymphocytecount and the level of PaCO2 were factors associated with prognosis in patients with AECOPD （P〈0.05）. The multivariateLogistic regression analysis showed that age, peripheral lymphocyte count and the level of PaCO2 were independent riskfactors for prognosis of patients with AECOPD （P〈0.05）. Conclusion There are many factors affecting the prognosis ofpatients with AECOPD, the patients with age 〉60 years, low peripheral lymphocyte count and high level of PaCO2 should befocused on monitoring, and take effective measures to improve the prognosis of patients.