7585名健康体检人群高尿酸血症检出率及相关因素分析

Analysis on the detection rate and related factors of hyperuricemia in 7585 health examination cases

目的调查分析健康体检人群血尿酸水平及高尿酸血症（HUA）检出率，探讨其相关因素。方法2016年1-12月采用整群抽样的方法，对深圳市某三甲医院特诊门诊7585名参加健康体检的人群进行体格和生化检查，运用百分数分析其检出率，应用Pearson相关分析、Logistic回归分析HUA的相关因素。结果该组人群HUA总检出率为32．76％，其中男性为32．88％，女性为32．69％；平均血尿酸水平为（358．98±91．11）μmol／L，其中男性血尿酸水平为（368．25±91．11）μmol／L，女性为（343．13±91．12）μmol／L。相关分析显示，男性、女性体检人群的血尿酸水平与收缩压、舒张压、BMI、总胆固醇、甘油三脂、低密度脂蛋白（LDL-C）呈正相关（P〈0．05），与高密度脂蛋白（HDL-C）呈负相关（P〈0．05）。回归分析显示，高收缩压、高甘油三酯、低LDL-C是HUA的独立危险因素，高HDL-C是HUA的保护因素。结论HUA常与高血压、高甘油三酯、低LDL-C伴发，医护人员在对血尿酸水平升高人群健康干预时应同时关注。

Objective To investigate and analyze the blood uric acid level and the detection rate of hyperuriccmia （HUA） and to discuss its related risk factors. Methods From January to December 2016, physical and biochemical examination were conducted to a total of 7585 cases with health examination, which were selected by using cluster sampling method. We analyzed the detection rate in percentage and the related factors of HUA by applying Pearson test and Logistic regression. Results Detection rate of HUA in this group was 32.76%, with 32.88% males and 32.69% females. The average blood uric acid level presented （358.98±91.11）μmol/L, of which male was （368.25±91.11）μmol/L and female was （343.13±91.12） μmol/L. Positive correlation was shown between blood uric acid levels and systolic blood pressure, diastolic blood pressure, BMI, total cholesterol, triglyceride, low density lipoprotein（LDL-C） （P 〈0.05）, while negative correlation was revealed between blood uric acid levels and high density lipoprotein（HDL-C）in both males and females （P〈0.05）. The independent risk factors of HUA were high systolic blood pressure, high triglyceride and low LDL-C, and the protective factor was high HDL-C. Conclusions Hyperuricemia is often associated with high systolic pressure, hypertriglyceridemia and low LDL-C. Attention should be paid when it comes to health interventions in people with elevated serum uric acid level.