调节肌肉合成代谢的新途径进展

Progress in the new approaches to regulation of muscle synthesis and metabolism

骨骼肌在人类健康以及疾病中发挥着重要的作用。在很多肿瘤、慢性心脏衰竭以及营养缺乏的状态下,会表现出以肌肉质量和力量丢失为特征的肌肉萎缩的症状。肌肉萎缩严重影响生存质量,甚至会威胁患者生命。虽然目前研究人员已经发现炎症和营养健康状态都会导致肌肉萎缩,但是具体的调控网络仍然不是很清楚。最近的研究揭示人体中肠道微生物可能也参与调控肌肉的合成代谢。因此,本文将综述最近有关"肠-肌"轴的研究进展以及所涉及的分子机制。

Skeletal muscle plays an important role in human health and disease. In many tumors, chronic heart failure and nutritional deficiency, the symptoms of muscular atrophy are characterized by loss of muscle mass and strength. Muscle atrophy seriously affects the quality of life, and even threatens the lives of patients. Although researchers have found that inflammation and nutritional health state can lead to muscle atrophy, the specific regulatory network is still not clear. Recent studies have revealed that gut microbes in the human body may also participate in the regulation of muscle synthesis. Therefore, we will review the recent progress in the study of the ＂gut muscle＂ axis and the molecular mechanisms involved.