针刺人迎穴联合祛风解毒活络汤治疗周围性面瘫的效果

Efficacy of acupuncture at Renying point combined with Qufeng Jiedu Huoluo Decoction on peripheral facial paralysis

目的探讨针刺人迎穴联合祛风解毒活络汤治疗周围性面瘫的效果。方法选取2014年10月～2017年12月杭州下城区中西医结合医院收治的93例周围性面瘫患者作为研究对象,按随机数字表法将其分为对照组(n=46)和治疗组(n=47),对照组患者给予人迎穴针刺治疗,治疗组患者给予祛风解毒活络汤联合针刺人迎穴治疗。评价临床疗效:采用双抗夹心酶联免疫(ELISA)法检测血清丙二醛(MDA)、超氧化物歧化酶(SOD)及一氧化氮(NO)水平;评价患者治疗前后House-Brackmann(H-B)分级评分;记录治疗过程中不良反应发生情况。结果治疗组总有效率明显高于对照组,差异有统计学意义(P <0.05)。治疗后,两组患者血清MDA水平明显低于治疗前,且治疗组低于对照组;血清SOD和NO水平均明显高于治疗前,且治疗组高于对照组,差异均有统计学意义(P <0.05)。治疗后,两组患者H-B分级评分明显低于治疗前,且治疗组低于对照组,差异有统计学意义(P <0.05)。结论针刺人迎穴联合祛风解毒活络汤治疗周围性面瘫的临床效果显著,能够明显改善血清MDA、SOD、NO水平,且安全性较好,值得在临床上推广应用。

Objective To study the efficacy of acupuncture at Renying point combined with Qufeng Hiedu Huoluo Decoction in patients with peripheral facial paralysis. Methods A total of 93 patients with peripheral facial paralysis admitted to Hangzhou Lower Urban Integrated Traditional Chinese and Western Medicine Hospital from October 2014 to December 2017 were selected as study objects. They were randomly divided into control group （n = 46） and treatment group （n = 47） according to random number table method. The control group was treated with acupuncture at Renying point, the treatment group was treated with Qufeng Jiedu Huoluo Decoction combined with acupuncture at Renying point. The clinical efficacy of the two groups were compared. The serum level of malondialdehyde （MDA）, superoxide dismutase （SOD） and nitric oxide （NO） were measured by double sandwich enzyme-linked immunosorbent assay （ELISA）, the House-Brackmann （H-B） score before and after treatment was evaluated, and the adverse reactions during treatment were recorded. Results The total efficacy rate of the treatment group was significantly higher than that of the control group, the difference was statistically significant （P ＜ 0.05）. After treatment, the level of serum MDA in the two groups were significantly lower than those before the treatment, which of the treatment group was lower than that of the control group; the level of serum SOD and NO were significantly higher than those before the treatment, and which of the treatment group were higher than those of the control group, the differences were statistically significant （P ＜ 0.05）. After treatment, the H-B score of the two groups were significantly lower than those before treatment, which of the treatment group was lower than that of the control group, the difference was statistically significant （P ＜ 0.05）. Conclusion Acupuncture at Renying point combined with Qufeng Jiedu Huoluo Decoction for patients with peripheral facial paralysis has a good efficacy, it can obviously improve the level of serum MDA, SOD and NO, it is safe and worthy of clinical application.