高脂血症性胰腺炎的临床特点分析

Analysis of clinical features of hyperlipemia pancreatitis

目的探讨高脂血症性胰腺炎患者临床特点,为进一步了解和治疗高脂血症性胰腺炎提供依据。方法选取2017年1月至2017年12月本院共收治各种原因的急性胰腺炎74例,其中高脂血症性胰腺炎22例,非高脂血症性胰腺炎52例;记录入院后24小时内血淀粉酶、血脂和血糖等指标,回顾住院期间患者局部及全身并发症发生情况,比较两组患者一般资料、生化指标及严重程度的不同。结果高脂血症性胰腺炎占胰腺炎的29%。血清TG明显高于非高脂血症性胰腺炎。高脂血症性胰腺炎血淀粉酶、胆固醇、低密度脂蛋白、ALT、AST、血糖水平、白细胞与非高脂血症性胰腺炎比较差异有统计学意义(P<0.01)。而TBIL、DBIL、血钙、CRP、D-二聚体与非高脂血症性胰腺炎比较无差异。严重程度分布为高脂血症性胰腺炎MAP 11例(50%),MSAP 9例(40.9%),SAP 2例(9.1%)。非高脂血症性胰腺炎MAP 35例(67.3%),MSAP 15例(28.8%),SAP 2例(3.85)。结论高脂血症性胰腺炎患者年龄偏低,血淀粉酶较非高脂血症性胰腺炎低,血脂多明显升高,且多伴有血糖异常,肝功能一般影响较小。中度-重度胰腺炎的发生率、局部并发症及全身并发症的发生率,与非高脂血症性胰腺炎相比差异无统计学意义。

Objective： to explore the clinical characteristics of hyperlipidemic pancreatitis （HPS） patients and provide a basis for further understanding and treatment of hyperlipidemic pancreatitis. Methods： from January 2017 to December 2017, 74 cases of acute pancreatitis of various reasons were admitted to our hospital, including 22 cases of hyperlipidemic pancreatitis and 52 cases of non-hyperlipidemic pancreatitis. Record within 24 hours after admission blood amylase, blood fat and blood sugar, review of hospital patients with local and systemic complications, compared two groups of patients＇ general information, and the severity of different biochemical indicators. Results： hyperlipidemic pancreatitis accounted for 29% of pancreatitis. Serum TG was significantly higher than non-hyperlipidemic pancreatitis （P〈0. 01）. There were significant differences in serum amylase, cholesterol, low-density lipoprotein, ALT, AST, blood glucose levels, white blood cells and non-hyperlipidemic pancreatitis （P〈0. 01）. There was no difference between TBIL, DBIL, blood calcium, CRP, D dimer and non-hyperlipidemic pancreatitis. The severity was distributed in MAP 11 cases （50%） of hyperlipidemic pancreatitis, MSAP 9 cases （40.9%） and SAP 2 cases （9.1%）. MAP showed 35 cases （67.3%） of non-hyperlipidemic pancreatitis, 15 cases （28.8%） of MSAP and 2 cases （3.8%） of SAP. Conclusion： hyperlipidemia low sex pancreatitis patients age, blood amylase was lower than those of non hyperlipidemia pancreatitis, lipid significantly increases, more and more associated with abnormal blood glucose, liver function is generally less affected. The incidence of moderate to severe pancreatitis, local complications and systemic complications were not significantly different from that of non-hyperlipidemic pancreatitis.