磷酸奥司他韦联合小儿豉翘清热颗粒治疗甲型流行性感冒的疗效及安全性分析

Efficacy and Safety of Oseltamivir Phosphate in Combination with Xiaoer Chiqiao Qingre Granule in Treating Influenza A

目的分析甲型流行性感冒应用磷酸奥司他韦、小儿豉翘清热颗粒联合治疗的效果及安全性。方法选取2016年12月至2017年12月在本院诊治的108例甲型流行性感冒患儿临床资料,按治疗方案不同分为对照组54例与观察组54例,对照组服用磷酸奥司他韦治疗,观察组在其基础联合小儿豉翘清热颗粒治疗,比较两组疗效及安全性。结果观察组治疗总有效率94.44%比对照组81.48%高,差异有统计学意义(P<0.05);观察组发热、鼻塞、咳嗽、咽喉充血缓解时间(30.02±8.42)h、(2.85±0.92)d、(2.45±0.22)d、(2.75±0.92)d均比对照组短,差异有统计学意义(P<0.05)。结论甲型流行性感冒应用磷酸奥司他韦、小儿豉翘清热颗粒联合治疗能有效缓解发热、咳嗽等症状,提高临床疗效,减轻炎症反应,且不增加药物不良反应效果显著。

Objective To analyze the efficacy and safety of combination therapy of oseltamivir phosphate and Xiaoer chiqiao qinger Granules in the treatment of type A influenza. Methods The clinical data of 108 influenza A children diagnosed and treated in our hospital from December 2016 to December 2017 were selected and divided into 2 groups according to the treatment protocol. 54 patients in each group were treated with oseltami- vir phosphate in the control group. The observation group was treated on the basis of its combination with Xiaoer chiqiao qinger Granules. The effica- cy and safety of the two groups were compared. Results The total effective rate of treatment in the observation group was 94.44% higher than that in the control group （81.48%） （P〈 0.05）. The fever, nasal congestion, cough, and throat congestion relief time in the observation group （30.02±8.42）h、（2.85±0.92）d、（2.45±0.22）dand（2.5±0.92）dd were shorter than those in the control group （P〈0.05）. Conclusion The combination therapy of os- eltamivir phosphate and Xiaoer chiqiao qinger Granules for type A influenza can effectively relieve fever, cough and other symptoms, improve clini- cal efficacy, reduce inflammation, and increase the adverse effects of drug.