REST在神经病理性疼痛中的研究进展

Research progress of REST in neuropathic pain

抑制元素1沉默转录因子/神经元限制性沉默因子(REST/NRSF)是一种转录抑制因子,它是一种DNA锌指结合蛋白,通过与一些基因中的特异的作用元件(NRSE)相结合,可以使其序列中的组蛋白发生去乙酰化,通过表观遗传重构来沉默靶基因,从而抑制靶基因的转录。近年来有研究表明,REST/NRSF介导诱导的几种特定基因的转录抑制是神经病理性疼痛发生和发展过程中的重要组成部分。该文就REST/NRSF与神经病理性疼痛之间的相关研究作一综述。

Repressor element-1 silencing transcription factor/the neuron-restrictive silencing factor（REST/NRSF） is a DNA zinc finger binding protein that binds to certain specific acting elements. The histones in their sequences can be deacetylated. REST/NRSF is a transcriptional repressor which acts via epigenetic remodeling to silence target genes. In recent years, several studies have shown that NRSF-mediated transcriptional repression of specific genes is an important component in the development and maintenance of neuropathic pain. This article reviews the recent studies on REST/NRSF and neuropathic pain.