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Mononuclear phagocyte system in hepatitis C virus infection 被引量:1

Mononuclear phagocyte system in hepatitis C virus infection
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摘要 The mononuclear phagocyte system (MPS), which con-sists of monocytes, dendritic cells (DCs), and macro-phages, plays a vital role in the innate immune defense against pathogens. Hepatitis C virus (HCV) is effcient in evading the host immunity, thereby facilitating its devel-opment into chronic infection. Chronic HCV infection is the leading cause of end-stage liver diseases, liver cirrhosis, and hepatocellular carcinoma. Acquired im-mune response was regarded as the key factor to era-dicate HCV. However, innate immunity can regulate the acquired immune response. Innate immunity-derived cytokines shape the adaptive immunity by regulating T-cell differentiation, which determines the outcome of acute HCV infection. Inhibition of HCV-specific T-cell responses is one of the most important strategies for im-mune system evasion. It is meaningful to illustrate the role of innate immune response in HCV infection. With the MPS being the important factor in innate immunity, therefore, understanding the role of the MPS in HCV infection will shed light on the pathophysiology of chronic HCV infection. In this review, we outline the impact of HCV infection on the MPS and cytokine production. We discuss how HCV is detected by the MPS and describe the function and impairment of MPS components in HCV infection. The mononuclear phagocyte system(MPS), which con-sists of monocytes, dendritic cells(DCs), and macro-phages, plays a vital role in the innate immune defense against pathogens. Hepatitis C virus(HCV) is efficient in evading the host immunity, thereby facilitating its devel-opment into chronic infection. Chronic HCV infection is the leading cause of end-stage liver diseases, liver cirrhosis, and hepatocellular carcinoma. Acquired im-mune response was regarded as the key factor to era-dicate HCV. However, innate immunity can regulate the acquired immune response. Innate immunity-derived cytokines shape the adaptive immunity by regulating T-cell differentiation, which determines the outcome of acute HCV infection. Inhibition of HCV-specific T-cell responses is one of the most important strategies for im-mune system evasion. It is meaningful to illustrate the role of innate immune response in HCV infection. With the MPS being the important factor in innate immunity, therefore, understanding the role of the MPS in HCV infection will shed light on the pathophysiology of chronic HCV infection. In this review, we outline the impact of HCV infection on the MPS and cytokine production. We discuss how HCV is detected by the MPS and describe the function and impairment of MPS components in HCV infection.
出处 《World Journal of Gastroenterology》 SCIE CAS 2018年第44期4962-4973,共12页 世界胃肠病学杂志(英文版)
关键词 Mononuclear phagocyte system Hepatitis C virus MONOCYTE Dendritic cell MACROPHAGE 病毒感染 丙肝病毒 免疫系统 吞噬细胞 cytokines HCV 免疫力 MPS
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