核苷(酸)类似物抗HBV获得病毒学应答后生化持续不应答原因

Advances in research on the causes of biochemical persistent non-response after nucleos(t)ide analogues-induced virological response in patients infected with hepatitis B virus

慢性乙型肝炎（CHB）病毒感染是我国肝硬化及肝癌的主要病因。核苷（酸）类似物（NA）抗乙肝病毒是治疗慢性乙型肝炎的关键,能最大限度地长期抑制乙肝病毒复制,减轻肝脏炎症、坏死及纤维化,延缓和减少肝脏失代偿、肝硬化、肝癌及并发症发生。