鼻导管高流量加温湿化正压通气和经鼻持续正压通气治疗新生儿呼吸窘迫综合征疗效比较

Comparison of the clinical effect of humidified high flow nasal cannula and nasal continuous positive airway pressure in treatment of neonatal respiratory distress syndrome

目的对鼻导管高流量加温湿化正压通气(HHFNC)和经鼻持续正压通气(NCPAP)治疗新生儿呼吸窘迫综合征(NRDS)的疗效进行对比研究。方法将我院2015年1月～2017年10月接收的74例NRDS患儿随机分为两组,对照组37例患儿采用NCPAPA治疗,观察组37例患儿HHFNC治疗,对比两组患儿的治疗效果及并发症发生情况。结果两组患儿治疗后12、24、72h血气指标均得到明显改善,且观察组明显优于对照组(P <0.05),观察组患儿舒适度明显优于对照组(P <0.05),观察组并发症发生率为2.70%,明显低于对照组的21.62%(P <0.05)。结论对新生儿呼吸窘迫综合征采用经鼻导管高流量加温湿化正压通气治疗,可有效提高治疗效果及患儿的舒适度,减少鼻损伤,值得临床应用推广。

Objective To compare and study the clinical effects of humidified high flow nasal cannula （HHFNC） and nasal continuous positive airway pressure （NCPAP） in treatment of neonatal respiratory distress syndrome （NRDS）. Methods Seventy-four NRDS neonates who were admitted and treated in our hospital from January 2015 to October 2017 were randomly divided the control group and the observation group,with 37 eases in each group.Neonates in the control group were treated by NCPAP while neonates in the observation group were treated by HHFNC.Clinieal effects aud the occurrence of complications of two groups were compared. Results Blood gas of after 12,24,72 hours after treatment in two groups were all improved significantly （P 〈 0.05）,and those of the observation group were better than the control group （P 〈 0.05）. The comfort level of observation group was higher than that of control group （P 〈 0.05）.Incidence of complications of the observation group was significantly lower than that of control group （P〈 0.05）. Conclusion HHFNC in treating NRDS can effectively improve curative effects and comfort level and reduce nasal damage,which is worthy of clinical application.