非那司提联合坦洛新应用于非细菌性前列腺炎患者的临床效果及对性功能的影响研究

Clinical effect of phenacetin combined with tamsulosin in patients with nonbacterial prostatitis and its effect on sexual function

目的:探讨非那司提联合坦洛新治疗非细菌性前列腺炎的临床效果以及对性功能的影响,提高患者的生活质量。方法:选择2015年3月至2017年2月在华北理工大学附属医院接受药物治疗的非细菌性前列腺炎患者104例,将其随机分为对照组和观察组,每组52例。对照组患者给予盐酸坦洛新口服,观察组患者在对照组基础上给予非那司提口服。对两组患者的临床症状进行评估,对治疗效果和治疗前后性功能、尿动力学进行评价。结果:观察组患者治疗总有效率高达98. 1%,对照组患者总有效率为86. 5%,两组差异具有统计学意义(P <0. 05);两组患者治疗前CPSI、IIEF-5、MFR和RVU比较,其差异均无统计学意义(均P> 0. 05);两组患者治疗后CPSI得分和RVU均有所降低,IIEF-5得分和MFR均有所升高,但观察组CPSI得分和RVU低于对照组,MFR高于对照组,两组差异均有统计学意义(均P <0. 05);两组患者IIEF-5得分差别不大,其差异无统计学意义(P> 0. 05)。结论:非那司提联合坦洛新治疗非细菌性前列腺炎可以有效改善患者的临床症状和性功能,与单纯使用坦洛新相比可以获得更好的治疗效果。

Objective：To evaluate the clinical effect of benitadine combined with tamsulosin in the treatment of nonbaeterial prostatitis and its effect on sexual function and improve the quality of life of patients. Methods ： 104 patients with nonbaeterial prostatitis who were treated in The Hospital Affiliated to North China University of Technology from March 2015 to February 2017 were randomly divided into control group and observation group. Fifty-two patients were randomly divided into control group and observation group. The control group was given oral tamsulosin oral, the observation group in the control group was given phenaeetin oral. The clinical symptonls of the two groups were evaluated, and the therapeutic effect and the sexual function and urodynamies were evaluated before and after treatment. Results： The total effective rate was 98.1% in the observation group and 86.5% in the control group, the observation group was significantly higher than the control group, the difference between the two groups was statistically significant （ P 〈 0.05 ） ; There were no significant differences in CPSI, IIEF-5, MFR and RVU between the two groups before treatment （all P 〉 0.05）. After treatment, the scores of CPSI and RVU were decreased, the scores of IIEF-5 and MFR were increased, but the CPSI score and RVU were lower in the observation group （all P 〈0.05）. There was no significant difference in the scores of IIEF-5 between the two groups （P 〉 0. 05）. Conclusions： The treatment of non-bacterial prostatitis with phenaeetin combined with tamsulapine can improve the clinical symptoms and sexual function of the patients, and can achieve better therapeutic effect compared with the use of tamsulosin alone.