米非司酮联合桂枝茯苓胶囊治疗子宫肌瘤的临床疗效及其对患者血清HE4和CA125水平的影响

Clinical effect of mifepristone combined with Guizhi Fuling Capsule on hysteromyoma and its influence on serum HE4 and CA125 levels

目的:分析米非司酮联合桂枝茯苓胶囊治疗子宫肌瘤的疗效,为临床用药提供有效依据。方法:选取2015年1月至2017年2月在武汉市第三医院接受治疗的120例子宫肌瘤患者作为研究对象,并利用随机数字表法将入选患者随机分为两组,即对照组和研究组。比较两组患者疗效、安全性及治疗前后血清内HE4以及CA125的水平变化。结果:对照组患者治疗总有效率为78. 30%,而研究组患者治疗总有效率为95. 00%,研究组患者治疗总有效率显著高于对照组患者,差异具有统计学意义(P <0. 05)。同时,治疗后两组患者子宫及肌瘤大小均显著减小,而研究组患者子宫及肌瘤大小均明显小于对照组患者,差异具有统计学意义(P <0. 05)。而且,治疗后研究组患者HE4、CA125水平均显著减小,而对照组则无显著变化,且研究组患者HE4、CA125水平均明显小于对照组患者,差异具有统计学意义(P <0. 05)。研究组患者不良反应发生率显著低于对照组患者,差异具有统计学意义(P <0. 05)。结论:米非司酮与桂枝茯苓胶囊联合治疗子宫肌瘤疗效显著、安全性高,且能够有效降低卵巢肿瘤的发生风险,值得进一步临床推广使用。

Objective：To analyze the efficacy of mifepristone combined with Guizhi Fuling Capsule in the treatment of uterine fibroids, in order to provide an effective basis for clinical medication. Methods： 120 hysteromyoma patients treated in our hospital from January 2015 to February 2017 were selected and randomly divided into two groups, the control group and the study group. The efficacy, safety and changes in serum levels of HFA and CA125 before and after treatment were compared between the two groups. Results： The total effective rate of the control group and study group was 78.3% and 95.0% respectively, with statistically significant difference （P 〈 0. 05 ）. The size of uterus and my-oma decreased significantly in the two groups after treatment, but the size of uterus and myoma in the study group was significantly smaller than that in the control group, with statistically significant difference （P 〈 0.05 ）. The levels of HFA and CA125 in the study group decreased significantly after treatment, but there was no significant change in the control group, and the levels of HFA and CA125 in the study group were significantly lower than those in the control group, with statistically significant difference （ P 〈 0.05 ）. The incidence of adverse reactions in the study group was significantly lower than that in the control group, with statistically significant difference （ P 〈 0.05 ）. Conclusions ： Mifepristone Combined with Guizhi Fuling Capsule is effective and safe in the treatment of uterine fibroids, and can effectively reduce the risk of ovarian tumors, which is worthy of further clinical application.