α受体阻滞剂联合PKRP术对前列腺增生患者尿道功能与生活质量的影响

Impact of α-receptor blockers combined with PKRP on the urethral function and life quality of patients with benign prostate hyperplasia

目的:探讨α受体阻滞剂联合经尿道双极等离子电切术(PKRP)对前列腺增生患者尿道功能与生活质量的影响。方法:选择2014年4月至2015年3月西安医学高等专科学校附属医院泌尿科诊治的108例良性前列腺增生患者为研究对象,根据入院时间先后顺序采用单双号方法将其分为观察组和对照组,每组54例患者。两组患者均择期行PKRP术,观察组患者术后联合应用α受体阻滞剂治疗。比较两组患者尿道功能、性功能、生活质量等指标。结果:术后6个月,观察组患者最大尿道关闭压(MUCP)、最大尿流率(Qmax)明显高于对照组患者,残余尿量(RU)、国际前列腺症状评分(IPSS)明显低于对照组患者(t=5. 282,8. 055,7. 922,8. 631,P <0. 05);精液精浆α-葡萄糖苷酶(α-Glu)、国际勃起功能指数-5 (IIEF-5)评分明显高于对照组患者,精浆酸性磷酸酶(ACP)含量明显低于对照组患者(t=4. 112,2. 777,4. 134,P <0. 05);疾病维度、生理维度、社会维度、心理维度、满意度维度等评分均明显高于对照组患者(t=6. 280,4. 880,4. 369,5. 966,4. 916,P <0. 05)。结论:α受体阻滞剂联合PKRP术有助于提高前列腺增生患者生活质量,可能与改善尿道功能和性功能有关。

Objective： To study the impact of α-receptor blockers combined with transurethral plasmakinetic prostatectomy（ PKRP） on the urethral function and life quality of patients with benign prostate hyperplasia（ BPH）.Methods： 108 patients with BPH from April 2014 to March 2015 were divided into observation group and control group according to the order of admission,each of 54 cases. All the patients underwent PKRP surgery,on which basis the observation group received α-receptor blockers therapy. The urinary function,sexual function and life quality was compared between the two groups. Results： At 6 months after surgery,the Maximum Urethral Closure Pressure（ MUCP） and Qmax in the observation group were significantly higher than those in the control group,while residual urine volume（ RU） and international prostate symptom score（ IPSS） were significantly lower than those of control group（ t = 5. 282,8. 055,7. 922,8. 631,P〈0. 05）. Semen α-Glu and IIEF-5 in the observation group were significantly higher than those in the control group,while semen ACP was significantly lower than that in the control group（ t = 4. 112,2. 777,4. 134,P〈0. 05）. The scores of disease dimension,physical dimension,social dimension,psychological dimension and satisfaction dimension were significantly higher than those in the control group（ t= 6. 280,4. 880,4. 369,5. 966,4. 916,P〈0. 05）. Conclusions： α-receptor blockers combined with PKRP is conductive to improving the life quality of patients with BPH,which may be related to the improvement in urinary function and sexual function.