探讨三氯醋酸和聚甲酚磺醛栓治疗宫颈癌患者术后阴道上皮内瘤变的临床疗效

To investigate the clinical efficacy of trichloroacetic acid and paclitaxel in the treatment of postoperative vaginal intraepithelial neoplasia in patients with cervical cancer

目的:分析并探讨三氯醋酸和聚甲酚磺醛栓治疗宫颈癌患者术后阴道上皮内瘤变(VAIN)的临床疗效,从而为治疗方案的选择提供参考依据。方法:选取2015年5月至2017年5月在唐山市妇幼保健院接受治疗的宫颈癌患者术后阴道上皮内瘤变患者160例。随机分为三氯醋酸组和聚甲酚磺醛栓组。两组患者均采用CO2激光术治疗。在此基础上,三氯醋酸组联合应用三氯醋酸治疗,聚甲酚磺醛栓组联合聚甲酚磺醛栓治疗。观察两组治疗效果。结果:三氯醋酸组治愈率为97. 50%。聚甲酚磺醛栓组治愈率为85. 00%。三氯醋酸组有效率明显高于聚甲酚磺醛栓组,差异具有统计学意义(P <0. 05)。三氯醋酸组转阴率为91. 25%。聚甲酚磺醛栓组转阴率为77. 50%。三氯醋酸组转阴率明显高于聚甲酚磺醛栓组,差异具有统计学意义(P <0. 05)。三氯醋酸组免疫功能明显优于聚甲酚磺醛栓组,差异具有统计学意义(P <0. 05)。三氯醋酸组生活质量明显高于聚甲酚磺醛栓组。经统计学检验,差异具有统计学意义(P <0. 05)。结论:与聚甲酚磺醛栓相比,CO2激光术联合应用三氯醋酸治疗宫颈癌患者术后阴道上皮内瘤变的临床效果更加显著,临床上值得推荐。

Objective： To analyze and explore the clinical efficacy of trichloroacetic acid and polyxylol sulfonal suppository in the treatment of postoperative vaginal intraepithelial neoplasia（ VAIN） in patients with cervical cancer,so as to provide a reference for the selection of treatment regimen. Methods： 160 patients with postoperative vaginal intraepithelial neoplasia were enrolled in this study from May 2015 to May 2017. Were randomly divided into trichloroacetic acid group and polyxylol sulfonamide group. Both groups were treated with CO2 laser. On the basis of this,trichloroacetic acid group combined with trichloroacetic acid treatment,poly（ xylsthenol sulfonyl phthalate group） combined with poly（ cresol）. Two groups of treatment were observed. Results： The cure rate of trichloroacetic acid group was 97. 50%. The cure rate of the chitosan sulfonamide group was 85. 00%. The effective rate of trichloroacetic acid group was significantly higher than that of the group（ P〈0. 05）. The conversion rate of trichloroacetic acid group was 91. 25%. The positive rate of poly（ cresol） was 77. 50%.（ P〈0. 05）,and the difference was statistically significant（ P〈0. 05）. The immunological function of trichloroacetic acid group was better than that of paclitaxel group（ P〈0. 05）. The quality of life of trichloroacetic acid group was significantly higher than that of polyhydrol group. The statistical test,statistically significant（ P〈0. 05）. Conclusion： Compared with polyphenols sulfonaldehyde suppository,CO2 laser combined with trichloroacetic acid in the treatment of cervical cancer patients with postoperative vaginal intraepithelial neoplasia clinical effect is more significant,clinically worthy of recommendation.