肾性贫血患者外周血红细胞参数与微炎症指标相关性分析

Detection of Erythrocyte Parameters in Patients with Renal Anemia and Its Correlation with the Index of Microinflammation

目的通过分析肾性贫血患者红细胞参数与微炎症指标的相关性,对肾性贫血患者微炎症做出有效提示,利于微炎症状态尽早纠正。方法选取2017年3月～2018年3月在肾内科住院的慢性肾衰竭(CRF)伴贫血患者120例作为病例组,选同期体检正常人群150例作为对照组。对病例组与对照组血细胞参数RBC,HGB,MCV,MCH,MCHC和RDW进行检测;对肾性贫血患者红细胞形态学进行检查;对微炎症相关指标CRP,ALB和A/G进行检测;对红细胞参数和微炎症指标进行相关性分析。结果病例组RDW和CRP明显高于对照组,RBC,ALB和A/G值明显低于对照组,差异均有统计学意义(P<0.05),病例组MCV,MCH和MCHC与对照组比较差异无统计学意义(P>0.05);细胞形态学提示,肾性贫血患者成熟红细胞普遍存着红细胞大小不等、异形性的特点;病例组RDW与CRP,ALB和A/G值存在相关性。结论肾性贫血以正细胞正色素性贫血为主,并伴有一定比例其他类型的贫血,RDW与微炎症状态有关,RDW可对肾性贫血患者处于微炎症状态起到提示作用。

Objective To analyze the correlation between changes of erythrocyte parameters of renal anemia patients and micro inflammatory state in order to make hints for early diagnosis of renal anemia and estimate micro inflammatory state. Methods Selected 120 samples of CRF patients in nephrology department from March 2016 to March 2017 as case group and selected 150 normal persons at the same time as matched group, and tested the blood routine parameters （RBC, HGB, MCV, MCH, MCHC and RDW） of two groups, red blood cell morphology, micro inflammatory state indexes （CRP, ALB, A/ G） and did statistical analysis of erythrocyte parameters and micro inflammatory state indexes. Results By microscopic examination of patients with RBC,it was common that the size of red cells was non-uniform distribution. The indexes （MCV, MCH and MCHC） of case group were normal, while there was apparent difference of RBC, RDW, CRP, ALB and A/G index between case group and matched group. The case group＇s RDW and CRP indexes were higher than matched group obviously, and RBC, ALB and A/G were lower than matched group. There was correlation between RDW and CRP, ALB and A/G in case group. Conclusion RDW can be regarded as evaluating indicator of micro inflammatory state, it also offers prompt effect for micro inflammatory state process of renal anemia patients.