摘要
目的:采用多指标综合评分与Box-Behnken响应面法,优选心痛宁胶囊的醇提工艺。方法:以阿魏酸含量、总黄酮含量、总厚朴酚含量和浸膏得率的综合评分为指标,在单因素试验结果的基础上,运用Box-Behnken响应面法对影响醇提工艺的提取次数、时间、加醇浓度、加醇倍量进行考察研究,从而得到最优的醇提工艺。结果:最佳醇提工艺为加10倍量60%的乙醇,回流提取2次,每次提取1 h。结论:优选后的工艺方便、稳定、可行,可为该课题后续研究的开展提供参考。
Objective: Through the nmlti-index comprehensive evaluation method combined with the Box-Behnken response surface method to optimizing the alcohol extraction process of Xin Tong Ning capsule. Methods : The contents of feru- lie acid flavonoids and honokiol, and extract yield were used as index, based on the results of single factor experiment, Box- Behnken response surface method was applied to optimize the ethanolie extraction process considering the extraction frequency, time, ethanol concentration. Results: The optimal parameters for ethanol extraction process were 10 times the amount of 60% ethanol, reflux extraction 2 times, each time lb. Conclusion: The optimized extraetiong process is convenient, stable and feasible, can provide theoretical basis for the further study.
作者
刘怡
如扎.哈布都拉
李露
王萍
孟瑶
李玉婷
依孜提.帕力哈提
张丽娟
聂继红
Ruzha.Habudula;LI Lu;WANG Ping;MENG Yao;LI Yu-ting;Yiziti Pilihati;ZHANG Li-juan;NIE Ji-hong(Xinjiang Medical University,U}umqi,830011,China;Fourth Clinical Medicine School of Xinjiang Medical University,U}umqi,830000,China)
出处
《中国现代中药》
CAS
2018年第11期1421-1426,1431,共7页
Modern Chinese Medicine
基金
新疆维吾尔自治区科技支疆项目(指令性)(201191167)