文拉法辛对单相抑郁患者IL-10和IL-4水平的影响

Influence of venlafaxine on interleukin-10 and interleukin-4 levels in patients with unipolar depression

目的观察单相抑郁患者白介素10(IL-10)、白介素4(IL-4)水平及文拉法辛对单相抑郁患者IL-10和IL-4水平的影响,探讨IL-10、IL-4水平与单相抑郁的关系及文拉法辛的抗抑郁机制。方法选取2016年6月-2017年12月于天津市安定医院就诊的符合《国际疾病分类(第10版)》(ICD-10)诊断标准的单相抑郁住院患者80例为病例组,给予文拉法辛治疗8周。同期选取天津市安定医院的健康体检者82例为对照组。于治疗前和治疗8周后采用酶联免疫吸附试验(ELISA)检测病例组IL-10、IL-4水平并用汉密尔顿抑郁量表24项版(HAMD-24)评定疗效,于入组时用ELISA检测对照组IL-10、IL-4水平。结果治疗前,病例组IL-10、IL-4水平均低于对照组,差异均有统计学意义(P均<0. 05)。治疗8周后,病例组IL-10、IL-4水平均高于治疗前,差异均有统计学意义(P均<0. 05);病例组与对照组IL-10、IL-4水平差异无统计学意义(P均> 0. 05)。治疗8周后,病例组HAMD-24总评分及焦虑/躯体化、迟缓、绝望感因子评分均低于治疗前,差异均有统计学意义(P均<0. 05)。病例组治疗前的IL-10、IL-4水平与HAMD-24评分呈负相关(r=-0. 772、-0. 654,P均<0. 05)。结论单相抑郁的发生可能与IL-10、IL-4水平降低相关,文拉法辛可改善单相抑郁患者的症状,其可能是通过调节IL-10、IL-4水平发挥抗抑郁作用。

Objective To observe the level of interleukin-10（IL-10） and interleukin-4（IL-4） and to analyze the effects of venlafaxine on the level of IL-10 and IL-4 in patients with unipolar depression,so as to explore the relationship between the levels of IL-10,IL-4 and unipolar depression as well as the antidepressant mechanism of venlafaxine. Methods A total of 80 patients in Tianjin Anding Hospital were selected as case group from June 2016 to December 2017. All of them were diagnosed with unipolar depression according to the International Classification of Diseases,tenth edition（ ICD-10） diagnostic criteria. All patients were treated with venlafaxine for 8 weeks. Meanwhile,82 healthy persons from Tianjin Anding Hospital were selected as control group.The levels of IL-10 and IL-4 in the case group were detected by enzyme linked immunosorbent assay（ ELISA） before treatment and8 weeks after treatment,and the efficacy was evaluated by Hamilton Depression Scale-24 items（ HAMD-24）. The levels of IL-10 and IL-4 in control group were detected by ELISA when they were selected. Results Before treatment,the levels of IL-10 and IL-4 in case group were lower than those in control group（ all P〈0. 05）. After 8 weeks of treatment,the levels of IL-10 and IL-4 in case group were higher than those before treatment（ all P〈0. 05）, there was no significant difference between the two groups（all P〉0. 05）. After 8 weeks of treatment,the total score of HAMD-24 and the scores of anxiety/somatization,retardation,despair factor were lower than those before treatment（ all P〈0. 05）. Before treatment,the levels of IL-10 and IL-4 were negatively correlated with the total score of HAMD-24（ r =-0. 772,-0. 654,all P〈0. 05） in case group. Conclusion The occurrence of unipolar depression may be related to the decrease of IL-10 and IL-4 levels. Venlafaxine can improve the depressive symptoms of patients with unipolar depression,which may play an antidepressant role by regulating the levels of IL-10 and IL-4.