强直性脊柱炎继发肾脏损害的治疗进展

Research progress on renal involvement secondary to ankylosing spondylitis and its treatment

强直性脊柱炎(AS)是一种主要累及骶髂关节和脊柱的炎症性疾病,关节外可累及全身多个器官,如肾脏、肺脏及心脏等。AS继发肾脏损害发病率约为10%～35%,国内外报道以肾淀粉样变性、肾小球肾炎和非甾体抗炎药相关的肾毒性及急性肾损伤为主,不同类型的肾脏损害有不同的治疗方案及预后。本文简要概述AS继发肾脏损伤的发病特征、临床表现及治疗进展。

Ankylosing spondylitis（AS） is an inflammatory disease which mostly affects vertebral column and sacroiliac joints. It can be accompanied by extra-articular manifestations in the renal, pulmonary and cardiovascular organs. However, the incidence of renal involvement secondary to AS is about 10%～35%. It is reported that the amyloidosis and glomerulonephritis, and the NSAIDs related nephrotoxicity and acute renal injury can be easily found in AS patients. Generally, the different types of renal damage have different treatment options and prognosis. This review describes the characteristics, manifestations and the treatment progress of renal involvement secondary to AS on treatment.