ICU超剂量谷红注射液成品输液的合理性考察

Reasonablity study of overdosage Guhong injection in ICU

目的建立ICU超剂量谷红注射液与5%葡萄糖注射液、0. 9%氯化钠注射液配伍后的成品输液于室内(约25℃)光照下放置24 h,考察ICU超剂量用药的合理性。方法以谷红注射液成品输液中4种有效成分含量、外观、不溶性微粒、pH值变化情况为指标,对该成品输液的稳定性进行考察。结果各成品输液于24 h均为深红棕色澄清溶液,未见明显变化,未出现浑浊及沉淀;不溶性微粒超出药典规定范围;其4种有效成分含量均呈下降趋势。结论该超剂量谷红注射液成品输液于24 h稳定性明显欠佳,该用药不合理,故不建议ICU超剂量用谷红注射液。

Objective To develop a method for determining reasonability of overdosage Guhong injection with 5% glucose injection and 0.9% NaC1 injection in indoor illumination within 24 h at room temperature （25 ℃） to examine the rationality of the overdosage drug in ICU. Methods The content of four active ingredients, appearance, insoluble particles and pH change in the finished product infusion of Guhong injection were used to indicate the stability of the finished product. Results All the finished products were dark reddish-brown elarifying solution in 24 h, no obvious change, no turbidity and precipitation. The insoluble particles exceeded the scope of the pharmacopoeia. The content of the four active components showed a decreasing trend. Conclusion It is not recommended to use overdosage Guhong injection in the ICU because of its unstability and unreseanability.