儿科住院患儿抗生素相关性腹泻临床分析

Clinical analysis of antibiotic-associated diarrhea in pediatric hospitalized children

目的分析儿科住院患儿抗生素相关性腹泻的临床特点及预防对策。方法选择儿科住院发生抗生素相关性腹泻患儿40例为腹泻组,另选择应用抗生素未发生抗生素相关性腹泻患儿40例为无腹泻组,观察腹泻组患儿的临床表现及预后,比较2组性别、年龄、抗生素种类、抗生素使用时间等。结果抗生素相关性腹泻发生在抗生素治疗的(4. 66±2. 13) d,单纯性腹泻36例,排便(4. 80±1. 39)次/d;严重腹泻伴发热、腹痛等4例;应用抗生素依次为:林可霉素、碳青酶烯类抗生素、头孢菌素等,治疗(3. 01±1. 03) d症状得到显著缓解,均痊愈出院。腹泻组禁食、侵袭性操作比例及抗生素种类、抗生素使用时间均高于无腹泻组,差异均有统计学意义(P <0. 05)。结论儿科住院患儿抗生素相关性腹泻发生率较高,具有一定特点,应实施相应的措施以避免减少抗生素相关性腹泻的发生。

Objective To analyze the clinical characteristics and preventive measures of antibiotic-associated diarrhea in pediatric hospitalized children. Methods 40 children with antibiotic-associated diarrhea in pediatric hospitalized children were selected as diarrhea group, and 40 children with antibiotic-associated diarrhea without antibiotics were selected as diarrhea-free gn）up,to observe the clinical manifestations and prognosis of the diarrhea group, the gender, age ,antibiotic type, and anti- biotic use time of the two groups were compared. Results Antibiotic-associated diarrhea occurred in antibiotics （4.66±2. 13 ） days, 36 cases of simple diarrhea, defecation （4.80±1.39）/day,4 cases of severe diarrhea accompanied by fever and abdominal pain. Use of antibiotics was as follows： lincomycin, carbapenem antibiotics, cephalosporin etc, treatment （3.01±1.03） days symptoms were significantly relieved, and all patients were cured and discharged. Conclusion The incidence of antibiotic associated diarrhea in pediatric hospitalized children is relatively high, with some characteristics, and corresponding measures should be taken to avoid the occurrence of antibiotic associated diarrhea.