丙戊酸钠联合富马酸喹硫平治疗双相障碍躁狂症的临床疗效

Clinical effect of sodium valproate combined with quetiapine fumarate in treating bipolar disorder

目的探讨丙戊酸钠联合富马酸喹硫平治疗双相障碍躁狂症的临床疗效。方法选取丰城市第四人民医院精神内科2014年9月—2017年9月收治的双相障碍躁狂症患者90例,随机分为对照组和试验组,各45例。对照组患者给予富马酸喹硫平治疗,试验组在对照组基础上联合丙戊酸钠治疗。比较两组患者治疗前后精神状态[贝克-拉范森躁狂量表(BRMS)、汉密尔顿抑郁量表(HAMD)及简明精神病量表(BPRS)评分],观察两组患者治疗期间不良反应发生情况(头痛、厌食、嗜睡、腹泻)。结果治疗前两组患者BRMS、HAMD及BPRS评分比较,差异无统计学意义(P>0.05);治疗后试验组患者BRMS、HAMD、BPRS评分低于对照组(P<0.05)。治疗期间试验组患者各不良反应发生率低于对照组(P<0.05)。结论丙戊酸钠联合富马酸喹硫平治疗双相障碍躁狂症的临床疗效确切,可有效减轻患者躁狂、抑郁程度,缓解精神障碍症状,且安全性高,利于患者康复。

Objective To explore the clinical effect of sodium valproate combined with quetiapine fumarate in treating bipolar disorder.Methods A total of 90 cases of patients with bipolar disorder were admitted from September 2016 to September 2017 in the Fourth People＇s Hospital of Fengcheng,which were randomly divided into control group and experimental group,45 cases in each group.The control group were treated with quetiapine fumarate,the experimental group were treated with sodium valproate based on the control group.The mental state（BRMS,HAMD,BPRS scores）before and after treatment was compared between the two groups,and the occurrence of adverse reactions（headache,anorexia,sleepiness,diarrhea） was observed during treatment.Results Before treatment,no statistically significant differences of the scores of BRMS,HAMD or BPRS was found between the two groups（P0.05）;after treatment,the experimental group of scores of BRMS,HAMD,BPRS were lower than those of control group（P0.05）.The incidence of adverse reactions in the experimental group was lower than that of control group（P0.05）.Conclusion Sodium valproate combined with quetiapine fumarate have an exactly clinical effect in the treatment of bipolar mania,which can reduce the severity of mania and depression,alleviate the symptoms of mental disorders,and with high safety,it is conducive to promote the rehabilitation of patients.