氟哌噻吨美利曲辛治疗胃溃疡伴抑郁症的临床疗效

Clinical effect of droperazidone metriaxine in the treatment of gastric ulcer with depression

目的探讨氟哌噻吨美利曲辛治疗胃溃疡伴抑郁症的临床疗效。方法选取达州市中西医结合医院2015年10月—2017年8月收治的胃溃疡伴抑郁症患者90例,采用随机数字表法分为对照组和试验组,各45例。对照组患者采取常规药物治疗,试验组患者在对照组基础上采用氟哌噻吨美利曲辛治疗,两组患者均连续治疗15 d。比较两组患者的临床疗效及治疗前后汉密尔顿抑郁评分量表(HAMD)评分,并观察两组患者不良反应发生情况。结果试验组患者临床总有效率高于对照组(P<0.05)。治疗前,两组患者HAMD评分比较,差异无统计学意义(P>0.05);治疗后,试验组患者HAMD评分低于对照组(P<0.05)。试验组患者不良反应发生率低于对照组(P<0.05)。结论氟哌噻吨美利曲辛治疗胃溃疡伴抑郁症的临床疗效确切,其可有效改善患者的临床症状及体征,缓解患其抑郁情绪,且安全性高。

Objective To explore the clinical effect of droperazidone metriaxine in the treatment of gastric ulcer with depression.Methods A total of 90 cases of gastric ulcer with depression patients were selected from October 2015 to August 2017 in Dazhou City Hospital of Integrated Traditional Chinese and Western Medicine,which were divided into control group and experimental group according to random number table method,45 cases in each group.The control group was treated with conventional treatment,the experimental group was treated with droperazidone metriaxine based on control group,both groups were treated for 15 days.The clinical effect,HAMD scores before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The total effective rate in experimental group was higher than control group（P0.05）.Before treatment,there was no significant difference of HAMD scores between the two groups（P0.05）;after treatment,the HAMD scores in experimental group was lower than control group（P0.05）.The incidence rate of adverse reactions in experimental group was lower than control group（P0.05）.Conclusion Droperazidone metriaxine has a significant therapeutic effect on patients with gastric ulcer and depression,which can improve the clinical symptoms of patients,and relief the depressive,and with high safety.