富氢水防治放射性口腔粘膜反应110例临床观察

Clinical observation of hydrogen-water on the treatment of acute radiation-induced oral mucositis of 110 cases

目的观察富氢水对急性放射性口腔粘膜反应的临床疗效。方法将110例接受放射治疗的鼻咽癌患者随机分为两组。治疗组55例,对照组55例。治疗组给予富氢水治疗,对照组给予等量生理盐水,至放疗结束。在放疗第2、4、6周评价患者口腔黏膜放射性损伤、吞咽功能及口腔黏膜疼痛程度。结果治疗组第4、6周对口腔粘膜放射损伤较对照组减轻(P <0. 05)。对吞咽功能的改善作用和对口腔黏膜疼痛的缓解作用优于对照组(P <0. 05)。结论富氢水可以改善放射性口腔黏膜反应。

Objective To observe the clinical effects of hydrogen-water on the treatment of acute ratiation-induced oral mucositis. Methods The 110 patients with nasopharyngeal carcinoma were randomiy divided into treatment group and control group. There were 55 cases in the treatment group and 55 cases in the control group. The treatment group was treated with hydrogen-rich water,while the control group was treated with normal saline until the end of radiotherapy. The clinical symptoms and signs of change,acute ratiation oropharyngeal mucosa reaction,swallowing function and the pain degree of oral mucosa were evaluated at the 2、4 and 6 weeks of radiotherapy. Results The acute radiation corop haryngeal mucosa reaction of treatment group at the 4、6 weeks of treatment was significantly more slight than control group（ P〈 0. 05）. The improvement of swallowing function and the remission of oral mucosa pain in treatment group at the 4,6 weeks of radiotherapy were better than that in control group（ P〈 0. 05）. Conclusion Hydrogen-rich water can improve radiation oral mucosa reaction.