高剂量率后装加外照射治疗气管金属支架植入后阻塞性肉芽增生——附四例分析

High-dose-rate brachytherapy plus external beam radiotherapy:A utilized modality for tracheobronchial obstructive granulation hyperplasia induced by self-expandable metallic stents

目的观察高剂量率近距离后装加体外照射治疗气管、支气管良性狭窄金属支架植入后引起的气管阻塞性炎性肉芽增生的疗效。方法采用高剂量率近距离后装加体外照射治疗4例因金属支架植入后所导致的气管阻塞性炎性肉芽肿患者,根据临床症状及支气管镜的检查结果对治疗效果进行评估。结果 4例患者中有3例呼吸困难症状明显缓解,行支气管镜检查显示肉芽增生组织较治疗前显著退缩。结论后装治疗联合外照射可能会成为治疗气管阻塞性肉芽肿的新的有效方法。

Objective To study the effect of high-dose-rate brachytherapy plus external beam radiotherapy（ HDRB plus EBR） for re-stricture induced by granulation hyperplasia after SEMS（ self-expandable metallic stents） implantation for benign tracheobronchial stricture. Methods 4 cases with re-stricture induced by granulation hyperplasia after SEMS implantation for benign tracheobronchial stricture were treated with high-dose-rate brachytherapy plus external beam radiotherapy,and the effect was evaluated according to the clinical symptoms alleviation and bronchoscopy result. Results 3 cases showed obvious dyspnea alleviation,and the granulation decreased obviously. Conclusion This study indicated that HDRB plus EBR might provide an effective therapeutic alternative for obstructive tracheal granulation hyperplasia.