老年2型糖尿病男性患者发生骨质疏松的临床特征及危险因素分析

Clinical characteristics and risk factors of osteoporosis in elderly male patients with type 2 diabetes mellitus

目的 探讨老年2型糖尿病男性患者发生骨质疏松的临床特征及相关危险因素.方法 回顾性分析2016年10月至2018年3月太原市中心医院治疗的102例老年2型糖尿病男性患者的临床资料,根据《原发性骨质疏松症诊治指南（2011年）》将所有患者分为骨质疏松组（35例）与非骨质疏松组（67例）,分析骨质疏松特征以及老年2型糖尿病男性患者发生骨质疏松的相关危险因素.结果 102例患者中,35例患有骨质疏松,患病率为34.31％;骨质疏松组骨密度低于非骨质疏松组,差异有统计学意义（P〈0.05）;两组三酰甘油（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、尿酸（UA）水平比较,差异未见统计学意义（P〉0.05）;骨质疏松组年龄、糖尿病病程、糖化血红蛋白（HbA1c）、C-反应蛋白（CRP）、总胆固醇（TC）均高于非骨质疏松组,体质指数（BMI）、空腹胰岛素水平（FINS）均低于非骨质疏松组,差异有统计学意义（P〈0.05）;经Logistic回归分析发现,年龄、BMI、糖尿病病程、HbA1c、FINS、CRP、TC是影响老年2型糖尿病男性患者发生骨质疏松的危险因素.结论 年龄、BMI、糖尿病病程、HbA1c、FINS等均为老年2型糖尿病男性患者发生骨质疏松的相关危险因素,应对以上因素进行合理控制,以减少预后风险.

Objective To investigate the clinical characteristics and risk factors of osteoporosis in elderly male patients with type 2 diabetes mellitus.Methods The clinical data of 102 elderly patients with type 2 diabetes in Taiyuan Central Hospital from October 2016 to March 2018 were retrospectively analyzed.According to the guidelines for the diagnosis and treatment of primary osteoporosis （2011）, all the patients were divided into osteoporosis group （35 cases） and non osteoporosis group （67 cases） .The osteoporosis characteristics and risk factors for osteoporosis in elderly men with type 2 diabetes mellitus was analyzed .Results Among the 102 patients, 35 cases had osteoporosis , the prevalence rate was 34.31％;BMD in osteoporosis group was lower than that in non osteoporosis group （ P〈0.05 ）; there was no significant difference in triglyceride （ TG ） , high density lipoprotein （ HDL-C ） , low density lipoprotein （ LDL-C ） , uric acid （ UA ） between the two groups （ P 〉0.05 ）; the age , duration of diabetes mellitus, HbA1c, CRP and TC in osteoporosis group were higher than those in non-osteoporosis group;the body mass index （ BMI） and fasting insulin level （ FINS） were significantly lower than those in non-osteoporosis group （ P〈0.05 ）; Logistic regression analysis showed that age , BMI, duration of diabetes mellitus, HbA1c, FINS, CRP and TC were risk factors for osteoporosis in elderly male patients with type 2 diabetes mellitus.Conclusions Age, BMI, duration of diabetes mellitus, HbA1c and FINS were risk factors for osteoporosis in elderly male patients with type 2 diabetes mellitus , the above factors should be reasonably controlled to reduce the risk of prognosis .