针刺内关穴预处理改善心肌缺血再灌注损伤机制的研究进展

Preconditioning of Needling PC6 Improving MIRI: A Study of Research Progress

心肌缺血再灌注损伤(MIRI)的防治工作是近年来研究的重点,内关穴为心包经的络穴、八脉交会穴,具有特异性心肌保护作用,历代医家均选此穴治疗心胸疾病。大量的研究证实针刺内关穴预处理能有效抑制再灌注时期氧自由基的形成,减轻Ca^(2+)超载及炎症反应的发生,从而对心肌细胞产生保护作用。本研究对近年来针刺内关穴预处理防治心肌缺血再灌注损伤的研究成果进行整理,并对其具体的作用途径进行总结,以期为针刺的MIRI临床防治工作提供理论依据和新的治疗思路。

Over past decades,many attentions have been paid to the prevention and the control of myocardial ischemia reperfusion injury（ MIRI）. Neiguan point（ PC6）,belonging to the pericardium meridian,is the luo-connecting point and one of the eight confluent acupoints. It has a specifically protective effect on heart muscle cells. PC6 is a priority in treating diseases of heart and chest by physicians. A large amount of researches have confirmed that the preconditioning of needling PC6 can effectively inhibit the formation of oxygen free radicals and reduce the overloading of Ca^2＋ and the occurence of inflammation during reperfusion,which could provide the protective effects for cardiomyocytes. This study sorted out the studies on the preconditioning of needling PC6 to prevent and pretreat MIRI. In addition,the specific ways of protective effects were summarized in order to provide theoretical guidance and give new therapy ideas for MIRI.