常见耳聋相关基因在非综合征型聋中的研究进展

Update to common deaf-related genes in non-syndromic hearing impairment

耳聋是一种很普遍的感音神经功能紊乱的耳部疾病，是人类最常见的致残原因之一，严重影响人类生活质量。在耳聋患者中遗传性聋约占60％。遗传性聋可分为综合征型聋和非综合征型聋。综合征型聋是指以耳聋合并其他临床症状的遗传综合征，而非综合征型聋是指以单一听力缺失为临床症状的遗传性疾病。本文对非综合征型聋的遗传性基因研究进展做一综述，以期从分子水平探讨耳聋的病因及发病机制。

Deafness is a common ear disease with sensorineural dysfunction. It is one of the most common causes of disability, which seriously affects the quality of human life. Hereditary deafness accounts for about 60% of deafness. Hereditary deafness can be divided into syndromic hearing impairmentus and non-syndromic hearing impairment. Syndromic hearing impairment is a hereditary syndrome in which deafness is associated with other clinical symptoms. Non-syndromic hearing impairment is a hereditary disease with single hearing loss as a clinical symptom. This article reviews the research progress of genetic genes in non-syndromic hearing impairment in order to explore the etiology and pathogenesis of deafness at molecular level.