肾移植后骨异常研究进展

Progress of bone disorders after renal transplantation

肾移植后骨异常主要表现为骨量丢失、矿化异常和易发骨折。终末期肾病的众多并发症可通过成功的肾移植改善,然而由于大部分患者移植前就存在肾性骨营养不良,移植后甲状旁腺激素水平居高不下,移植后肾功能再次恶化,移植后激素及免疫抑制剂等药物治疗的影响,骨异常问题在肾移植后很常见,是影响肾移植受者预后的重要因素。本文就近年来肾移植术后骨异常的研究进展作一简述。

Post-transplantation bone disease is characterized by changes in bone quality and density as well as mineral metabolism, which contribute to increased fracture risk. Many complications of end-stage renal disease can be improved by successful kidney transplantation. Because most patients have renal osteonystrophy before transplantation, the level of parathyroid hormone after transplantation is high, the renal function is further deteriorated after transplantation, and the effects of glucocorticoid and immuno-snppressive drugs after transplantation, bone disorders are common after renal transplantation, which are important factors affecting the prognosis of recipients.In this review, we reviewed research progress in bone disorder after renal transplantation.