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替莫唑胺配合放疗治疗高级别脑胶质瘤108例分析

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摘要 目的探讨替莫唑胺配合放疗对高级别脑胶质瘤的治疗效果及安全性。方法回顾分析我院收治的高级别脑胶质瘤患者216例分组研究,观察组患者术后在放疗基础上配合替莫唑胺进行治疗,对照组患者仅接受术后放疗治疗,对比两组患者疗效、生存率及不良反应。结果观察组有效率(78.70%)高于对照组(43.52%);观察组患者1年、2年、3年生存率明显高于对照组;观察组患者中位生存时间(25±4.27)月明显高于对照组(16±2.53)月。结论替莫唑胺配合放疗可明显改善高级别脑胶质瘤患者的近期疗效,提高患者生存率,具有较大临床应用价值。
作者 齐书然
出处 《首都食品与医药》 2018年第20期57-57,共1页 Capital Food Medicine
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  • 1Liang D, Schulder M. The role of intraoperative magnetic resonance imaging in glioma surgery [ J ] . Surg Neurol Int, 2012, 3 ( Suppl 4 ): S320-S327.
  • 2Stupp R, Mason WP, Van den Bent M J, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma [J]. NEngl J Med, 2005, 352 ( 10 ) : 987-996.
  • 3Hau P, Koch D, Hundsberger T, et al. Safety and feasibility of long- term temozolomide treatment in patients with high-grade glioma [ J ] . Neurology, 2007, 68 ( 9 ) : 688-690.
  • 4Khasraw M, Bell D, Wheeler H. Long-term use of temozolomide : could you use temozolomide safely for Life in gliomas? [ J ] . J Clin Neurosci, 2009, 16 ( 6 ) : 854-855.
  • 5Seiz M, Krafft U, Freyschlag CF, et al. Long-term adjuvant administration of temozolomide in patients with glioblastoma multiforme : experience of a single institution [ J ] . J Cancer Res Clin Oncol, 2010, 136 ( 11 ) : 1691-1695.
  • 6Darlix A, Banmann C, Lorgis V, et al. Prolonged administration of adjuvant temozolomidc improves survival in adult patients with glioblastoma [ J ] . Anticancer Res, 2013, 33 ( 8 ) : 3467-3474.
  • 7Mannas JP, Lightner DD, Defrates SR, et at. Long-term treatment with temozolomide in malignant glioma [ J ] . J Clin Neurosci, 2014, 21 ( 1 ) : 121-123.
  • 8Galldiks N, Kracht LW, Burghaus L, et at. Patient-tailored, imaging-guided, tong-term temozolomide chemotherapy in patients with glioblastoma [ J ] . Mol Imaging, 2010, 9 ( 1 ) : 40-46.
  • 9Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study : 5-year analysis of the EORTC-NCIC trial[ J ]. Lancet Oncol, 2009, 10( 5 ): 459-466.
  • 10Chen C, Xu T, Lu Y, et at. The efficacy of temozolomide for recurrent glioblastoma muhiforme [ J ]. Eur J Neurol, 2013, 20 ( 2 ) : 223- 230.

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